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ISIDORe project home / Services / In vivo models

In Vivo Models

All the models you need for advancing your research on epidemic-prone pathogens

SERVICES PROVIDED TO YOU BY: VetBioNet, Transvac, Infrafrontier & ERINHA

ISIDORe will only offer access to in vivo models in the absence of adequate alternative methods to achieve an identical result (REPLACE). Please do not forget to check out our wide range of EX VIVO MODELS.

When in vivo models cannot be substituted with any other comparable method, we will use the smallest number necessary for quality science (REDUCE), as well as state-of-the-art practices to protect animal welfare and prevent animal pain and distress (REFINE).

Positively evaluated requests for access to in vivo models will be subjected to institutional ethical evaluation before any implementation can happen.

The services listed below are a general overview of ISIDORe’s in vivo capacities. Models are not available for all species and/or all pathogens. If you want to make sure that we can provide access to your model of interest, please contact us: exvivo-invivo-services@isidore-project.eu

MODELS FOR INFECTION STUDIES

Please note that agents from the Plasmodiidae and Trypanosomatidae famililes can only be studied in Arthropods. Main exceptions are indicated in brackets. Other specific exceptions may apply.

Provided to you by: VetBioNet, Infrafrontier & ERINHA

Contact
exvivo-invivo-services@isidore-project.eu

  • Mouse1
  • Hamster (not available for RG4 pathogens)
  • Guinea Pig (not available for vector-borne pathogens)
  • Rabbit
  • Ferret
  • Pig1,3
  • Sheep5 (not available for RG4 pathogens)
  • Cattle (not available for RG4 pathogens)
  • Non-human primates
  • Livestock
  • Camelids (not available for RG4 pathogens)
  • Chicken2 (not available for RG4 pathogens)
  • Fruitbats (not available for RG4 pathogens)
  • Wildlife2,4 (not available for RG4 pathogens)
  • Zebrafish (not available for RG4 pathogens)
  • Arthropods (Only available for vector-borne pathogens)

1 Includes models expressing human ACE2
2 Includes avian influenza models
3 Includes pig influenza models
4 Includes vector-transmission models
5 Includes pregnant sheep models

MODELS FOR DRUG EFFICACY STUDIES

Please note that agents from the Plasmodiidae and Trypanosomatidae famililes can only be studied in Arthropods. Main exceptions are indicated in brackets. Other specific exceptions may apply.

Provided to you by: VetBioNet, Infrafrontier & ERINHA

Contact
exvivo-invivo-services@isidore-project.eu

  • Mouse1
  • Hamster (not available for RG4 pathogens)
  • Guinea Pig (not available for vector-borne pathogens)
  • Rabbit
  • Ferret
  • Pig1,3
  • Sheep5 (not available for RG4 pathogens)
  • Cattle (not available for RG4 pathogens)
  • Non-human primates
  • Livestock
  • Camelids (not available for RG4 pathogens)
  • Chicken2 (not available for RG4 pathogens)
  • Fruitbats (not available for RG4 pathogens)
  • Wildlife2,4 (not available for RG4 pathogens)
  • Zebrafish (not available for RG4 pathogens)
  • Arthropods (Only available for vector-borne pathogens)

1 Includes models expressing human ACE2
2 Includes avian influenza models
3 Includes pig influenza models
4 Includes vector-transmission models
5 Includes pregnant sheep models

MODELS FOR VACCINE EFFICACY STUDIES

Please note that agents from the Plasmodiidae and Trypanosomatidae famililes can only be studied in Arthropods. Main exceptions are indicated in brackets. Other specific exceptions may apply.

Provided to you by: VetBioNet & ERINHA

Contact
exvivo-invivo-services@isidore-project.eu

  • Mouse1
  • Hamster (not available for RG4 pathogens)
  • Guinea Pig (not available for vector-borne pathogens)
  • Rabbit
  • Ferret
  • Pig1,3
  • Sheep5 (not available for RG4 pathogens)
  • Cattle (not available for RG4 pathogens)
  • Non-human primates
  • Livestock
  • Camelids (not available for RG4 pathogens)
  • Chicken2 (not available for RG4 pathogens)
  • Fruitbats (not available for RG4 pathogens)
  • Wildlife2,4 (not available for RG4 pathogens)
  • Zebrafish (not available for RG4 pathogens)
  • Arthropods (Only available for vector-borne pathogens)

1 Includes models expressing human ACE2
2 Includes avian influenza models
3 Includes pig influenza models
4 Includes vector-transmission models
5 Includes pregnant sheep models

MODELS FOR VACCINE IMMUNOGENICITY STUDIES

Provided to you by: VetBioNet, Transvac & EMBRC

Contact
exvivo-invivo-services@isidore-project.eu

  • Mouse
  • Hamster
  • Rabbit
  • Ferret
  • Pig
  • Sheep
  • Cattle
  • Non-human primates
  • Camelids
  • Chicken
  • Wildlife Zebrafish

MODELS FOR VECTOR RESEARCH

All of the vectors listed below can be provided free of pathogens. Some of the vectors listed below are provided ONLY free of pathogens and are marked with an *. If you want to make sure that we can provide access to your vector of interest, please contact us.

Provided to you by: INFRAVEC

Contact
TNAManager@infravec2.eu

Aedes spp (available pathogen-free and carrying members of the Flaviviridae, Togaviridae & Trypanosomatidae1 families)
Anopheles spp(available pathogen-free and carrying members of the Flaviviridae and Plasmodiidae families)
Culex spp(available pathogen-free and carrying members of the Flaviridae family)
Culocoides spp*(avalaible pathogen-free only)
Glossina spp*(avalaible pathogen-free only)
Hyalomma spp*(avalaible pathogen-free only)
Lutzomyia spp(available pathogen-free and carrying members of the Trypanosomatidae1 family)
Ornithodoros spp*(avalaible pathogen-free only)
Phlebotomus spp(available pathogen-free and carrying members of the Trypanosomatidae1 family)
Rhipicephalus spp*(avalaible pathogen-free only)
Sergentomyia spp(available pathogen-free and carrying members of the Trypanosomatidae1 family)
Stomoxys spp*(avalaible pathogen-free only)
Table 1: Provided vectors

1 including Leishmania

GENERATION OF NEW STUDY MODELS FOR SARS-CoV-2 RESEARCH

Provided to you by: Infrafrontier

Contact
Asrar Ali KHAN
asrar.khan@infrafrontier.eu

  • Generation of precision mouse models
    • Humanization of mouse model cohorts by AAV-driven hACE2 expression
    • Generation of knock-out mice (service starting 2023)
    • Generation of knock-in mice (service starting 2023)