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ISIDORe project home / Services / In vivo models

In Vivo Models

All the models you need for advancing your research on SARS-CoV2.

SERVICES PROVIDED TO YOU BY: VetBioNet, Transvac, Infrafrontier & ERINHA

ISIDORe will only offer access to in vivo models in the absence of adequate alternative methods to achieve an identical result (REPLACE). Please do not forget to check out our wide range of EX VIVO MODELS.

When in vivo models cannot be substituted with any other comparable method, we will use the smallest number necessary for quality science (REDUCE), as well as state-of-the-art practices to protect animal welfare and prevent animal pain and distress (REFINE).

Positively evaluated requests for access to in vivo models will be subjected to institutional ethical evaluation before any implementation can happen.

MODELS FOR INFECTION STUDIES

Provided to you by: VetBioNet, Infrafrontier & ERINHA

Contact
Sascha Trapp
sascha.trapp@inrae.fr

  • Infection studies in mice
    • Wild-type
    • K18 promoter/hACE2
    • mACE2 promoter/hACE2
    • CMV promoter/hACE2
    • Conditional expression of hACE2
  • Infection studies in hamsters
  • Infection studies in ferrets
  • Infection studies in non-human primates
  • Infection studies in hACE2 pigs
  • Infection studies in livestock and wildlife species

MODELS FOR DRUG EFFICACY STUDIES

Provided to you by: VetBioNet, Infrafrontier & ERINHA

Contact
Sascha Trapp
sascha.trapp@inrae.fr

  • Drug efficacy studies in mice
    • Wild-type
    • K18 promoter/hACE2
  • Drug efficacy studies in hamsters
  • Drug efficacy studies in ferrets
  • Drug efficacy in non-human primates
  • Drug efficacy in hACE2 pigs

MODELS FOR VACCINE EFFICACY STUDIES

Provided to you by: VetBioNet & ERINHA

Contact
Sascha Trapp
sascha.trapp@inrae.fr

  • Vaccine efficacy studies in mice
    • Wild-type
    • K18 promoter/hACE2
  • Vaccine efficacy studies in hamsters
  • Vaccine efficacy studies in ferrets
  • Vaccine efficacy studies in non-human primates
  • Vaccine efficacy studies in hACE2 pigs

MODELS FOR VACCINE IMMUNOGENICITY STUDIES

Provided to you by: VetBioNet & Transvac

Contact
Sascha Trapp
sascha.trapp@inrae.fr

  • Vaccine immunogenicity studies in mice
  • Vaccine immunogenicity studies in hamsters
  • Vaccine immunogenicity studies in ferrets
  • Vaccine immunogenicity studies in non-human primates
  • Vaccine immunogenicity studies in pigs
  • Studies of adjuvanted formulations in a variety of species

GENERATION OF NEW STUDY MODELS FOR SARS-CoV-2 RESEARCH

Provided to you by: Infrafrontier

Contact
Asrar Ali KHAN
asrar.khan@infrafrontier.eu

  • Generation of precision mouse models
    • Humanization of mouse model cohorts by AAV-driven hACE2 expression
    • Generation of knock-out mice
    • Generation of knock-in mice