Tackling Drug-Resistant Tuberculosis: A Structural Insight into Efflux Pumps
As part of the ISIDORe project, Joana Santos from i3S (Portugal) collaborated with Instruct-ERIC’s Membrane Protein Production Lab at Diamond...
ISIDORe success stories: Success stories
Strengthening Community Engagement in the Fight Against Tickborne Diseases
Through ISIDORe, researchers from the Institut Pasteur’s Anthropology and Ecology of Disease Emergence unit accessed the MORU Community Engagement...
Adoptive Memory T Cell Therapy Shows Promise in Phase 2 COVID-19 Clinical Trial
Supported by ISIDORe, a phase 2 multicenter clinical trial led by IdiPAZ-FIBHULP (Spain) in collaboration with Oslo University Hospital (Norway)...
Addressing Ethical Challenges in Sharing Qualitative Research Data During Pandemics
The COVID-19 pandemic has brought renewed attention to the importance of open data sharing to improve epidemic preparedness and response. However,...
Combatting Leishmaniasis: Advancing Sand Fly Monitoring and Resistance Managementg
A groundbreaking study in PLOS Neglected Tropical Diseases sheds light on innovative tools for monitoring sand flies, the primary vectors of...
Improving Epidemic Response through Social Science Training in Africa
This project aimed to enhance the ability of healthcare professionals in Africa to respond more effectively to epidemics by incorporating social and...
SARS-CoV-2 Therapeutics Development
Led by researcher Kurt Zatloukal, focused on developing therapeutics to block SARS-CoV-2 infections and replication, particularly by inhibiting the...
Nasal Spray Formulation of LTX-109 as a Therapeutic for SARS-CoV-2 and Influenza
Pharma Holdings, led by Johnny I. Ryvoll in Norway, sought regulatory advice from EATRIS regarding the development of a nasal spray formulation for...
Regulatory Advice for the Development of a Virus-Like Particle Vaccine Platform
Alexander Jerman from Sferogen, a pre-clinical stage biotech company in Slovenia, sought regulatory advice regarding the development of their...
NMR Binding Studies of Antiviral Compounds Targeting SARS-CoV-2
Led by Prof. Amadeu Llebaria from Barcelona, Spain, this project aimed to explore the binding properties of two families of antiviral compounds...
Aptamers for Lyme Disease Diagnostics through SELEX Technology
Dr. Séverine Padiolleau from France led a project, supported by ISIDORe, aimed at developing new diagnostic probes for Lyme borreliosis, a...
Exploring Asparagine Deamidation in SARS-CoV-2 Receptor-Binding Domain and Its Impact on Neutralizing Antibody Binding
Dr. Leonardo Alonso from Argentina, with support from Instruct-ERIC and EMBL Hamburg, led a project to explore the effect of deamidation at position...
Nanobody Discovery for Bunyavirus Polymerase Structural Studies
Dr. Jeremy Keown, from the United Kingdom, collaborated with Instruct-ERIC and VIB VZW in Brussels through the ISIDORe project to generate...
Cryo-ET to understand how enteroviruses replicate
Enteroviruses cause a range of diverse diseases in humans, like polio or viral myocarditis. While there is a vaccine available for polio, the...
Immunoinformatics Design for MPox Virus Serosurveillance
The University of Buea in Cameroon, in collaboration with European research infrastructures ERINHA and IGBMC (an Instruct-ERIC member), undertook a...
Rapidly Detecting Mpox
In response to the 2022 Monkeypox outbreak in non-endemic regions, Coris BioConcept, in partnership with INMI, initiated the development of a...
Investigating Crimean-Congo Hemorrhagic Fever Virus in Corsica
Dr. Remi Charrel and his team at the Unité des Virus Emergents (UVE) in Aix-Marseille University, France, aimed to assess the risk of Crimean-Congo...
Community Engagement in the Mpox Response
Dr. Paul Grohma and his team at the Medical University of Vienna have undertaken an important project to evaluate community engagement strategies...
Broad-Spectrum Inhibitors Against Coronaviruses Broad-Spectrum
Dr. Duc Duy Vo and his team at Uppsala University are focused on identifying non-covalent small-molecule inhibitors of the SARS-CoV-2 main protease...
Assessing the Susceptibility of Rats to Mpox Virus
Dr. Barry Rockx and his team at Wageningen Bioveterinary Research, the Netherlands, are investigating the potential for rats to serve as reservoirs...
Mitigating COVID-19 Virulence
Dr. Fernando J. Montero Segovia and his team at the University of Granada, Spain, are researching ways to mitigate COVID-19 virulence by targeting...
Informational Practices and Aspirations of Long COVID Patients
Dr. Jonathan Sobel and his team at the Institute of Global Health, University of Geneva, Switzerland, are conducting a mixed-methods study to...
SARS-CoV-2 Helicase Inhibitors Screening
Dr. Giulio Vistoli and his team at the Department of Pharmaceutical Sciences, University of Milan, Italy, are exploring the therapeutic potential of...
Evaluating Metformin for Pulmonary Tuberculosis treatment
Dr. Nibedita Rath and her team are conducting a randomized, controlled, open-label Phase III trial to evaluate the efficacy and safety of metformin...
Targeted Drug Delivery for SARS-CoV-2
Dr. Veronika Huntosova and her team at the Center for Interdisciplinary Biosciences, Technology and Innovation Park, Pavol Jozef Šafárik...
Advancing Regulatory Roadmaps for DNA Vaccine Development
Dr. Mireia López Siles and her team at the Universitat de Girona, Spain, are spearheading the development of KlebsiGene, a prophylactic DNA vaccine...
Innovative Antibody Research
Dr. Mireia Pelegrin and her team at Institute for Regenerative Medicine and Biotherapy, Montpellier, France, embarked on a groundbreaking project to...
Unlocking the secrets of malaria oocyst reproduction in the mosquito midgut
Nedal Darif, PhD scientist at EMBL’s volume correlative microscopy team, has dedicated his talents to dissecting replication mechanisms of the...
X-ray studies help design better anti-SARS-CoV-2 compounds
Dr Simone Di Micco’s group from the European Biomedical Research Institute of Salerno specialises in the design of bioactive compounds. At the...
Empowering Surveillance: Strengthening Europe’s Defense Against West Nile Virus
The "Surveillance & Epidemic Management" project led by Dr. Marco Brustolin from the Institute of Tropical Medicine in Antwerp, Belgium, focused...
Automatic pipeline for brain autoradiography image analysis
Zuzana Čočková, PhD, from Charles University and Francisco Lopez-Picón, PhD, from Turku PET Centre developed the Mouse Brain Alignment Tool...
A variant-proof monoclonal antibody (mAb) against SARS-CoV-2
Dr Harold Marcotte from the Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine of the Karolinksa Institutet...
How COVID-19 changes the structure of the heart: a multiscale multimodal 3D analysis
Angelika Svetlove is a PhD student at the Max Planck Institute for Multidisciplinary Sciences, Göttingen, whose project focuses on understanding...
Guarding Against COVID-19: LTX-109’s Nose-Saving Role in Fighting the Virus
Torsteinn Erlingsson conducted in vitro and in vivo studies of a drug candidate against SARS-CoV-2 at the Istituto Zooprofilattico Sperimentale...
Malaria parasites in the mosquitoes: imaging a needle in a haystack
Malaria is still a major public health problem, affecting more than 250 million people every year. The transmission of the disease relies on the...