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ISIDORe project home / Calls / Monkeypox virus

Monkeypox virus

ISIDORe emergency call for proposals.

About this call

Since early May, there has been a sudden and unexpected multi-country increase in monkeypox virus (MPXV) infections.

A global research consultation was recently held by the World Health Organization to discuss knowledge gaps and research priorities.

Based on the outcomes of this consultation and the need for an immediate research response to address and control better this outbreak before it worsens, the ISIDORe consortium announces the launch of an emergency call for proposals to support scientists researching MPXV. This complements the initiatives of BY-COVID, including data submission guidelines and MPXV sequences on the pathogen portal.

Your request for free of charge transnational access to ISIDORe capacities for supporting and advancing your research on MPXV must be focused on one of the topics listed below.

Please note that we expect proposals to be focused on basic or preclinical research.

Our capacities to support MPXV research currently include, but are not necessarily limited to: whole genome sequencing, imaging, structural biology, in vitro & in vivo models for studying infection mechanisms, testing of diagnostic devices, stability testing, etc. 

For example, if you have DNA from clinical or environmental samples that you need to be sequenced, or if you want to determine the structure of a complex between a MPXV protein and a host protein, etc, you can apply for free of charge access to the relevant services.

To submit your pre‑application:

  • Please make sure that you have read our eligibility conditions 
  • Select your research topic in the list below
  • Fill out and submit the ISIDORe pre-application form at the bottom of this page before 05 August 2022, 23:59 CEST. You will receive a notification with your ISIDORe project number. The ISIDORe team will then reach out to you to discuss the capacities that you need access to. If your request is feasible, you will be provided with additional guidelines for the preparation of your full application.

Applications must adhere to the relevant ethical and safety standards and will be evaluated according to the usual procedures in place in the research infrastructures of the ISIDORe consortium.

SECTION 1: SURVEILLANCE, TRANSMISSION & EPIDEMIC RISK MANAGEMENT

Proposals are expected to describe research focusing on either one of the following topics:

  • Topic MPX1.1: ONE HEALTH MPXV animal reservoirs and transmission
    For this topic, we expect projects describing research aiming at understanding animal-to-human transmission and animal reservoirs. This includes potential MPXV animal reservoirs: vulnerability of European rodents and other mammalian species to MPXV; identification of the reservoir(s) in endemic countries, etc. Only proposals focusing on livestock and wildlife species are eligible.
    Please note that a similar topic is open in the SARS-CoV-2 call for proposals (topic SC1.5), and that projects proposing research on both topics (SARS-CoV-2 & MPXV) will be prioritized (e.g., optimization of the analysis of similar samples, etc.)
  • Topic MPX1.2: Infection prevention and control
    This includes projects with an interest in the presence and persistence of MPXV in bodily fluids or on surfaces, susceptibility to disinfectants, wastewater monitoring, etc.

SECTION 2: MPXV NATURAL HISTORY

We will accept proposals focused on either one of the following topics:

  • Topic MPX2.1: Deciphering host-pathogen interactions.
  • Topic MPX2.2: Investigating MPXV-induced immune responses
  • Topic MPX2.3: Studying the virulence of MPXV, including the role of mutations
  • Topic MPX2.4: Comparing MPXV clades

SECTION 3: DIAGNOSTICS

Proposals should describe research focusing on either one of the following topics:

  • Topic MPX3.1: The development or optimization of diagnostic tools and methods, including ELISA, enabling quick responses in human populations.
  • Topic MPX3.2: ONE HEALTH Specific & IgM serological assays for human or animal populations. While proposals focusing on diagnostic in animals will be considered, proposals describing diagnostic tools for human populations will be prioritized.
  • Topic MPX3.2: ONE HEALTH Molecular assays for human or animal populations. While proposals focusing on diagnostic in animals will be considered, proposals describing diagnostic tools for human populations will be prioritized.

SECTION 4: THERAPEUTICS

NO TOPIC CURRENTLY OPEN

SECTION 5: VACCINES

We are interested in receiving proposals that describe research focused on either one of the following topics:

  • Topic MPX5.1: Efficacy of human vaccines (pre- & post-exposure) and vaccine-induced immunity
  • Topic MPX5.2: The cross‑protection induced by vaccines showing efficacy against POXV and its duration

SECTION 6: SOCIAL SCIENCES & EPIDEMIOLOGY

Proposals should focus on either one of the following topics:

  • Topic MPX6.1: Investigate lay (non-specialist) concepts of MPX and risk among specific social groups, as well as social stigma associated with illness from MPXV
  • Topic MPX6.2: Understanding the behavioral and social drivers of POXV vaccine and therapeutics uptake
    Please note that a similar topic is open in the SARS-CoV-2 call for proposals (topic SC6.1), and that projects proposing research on both topics (SARS-CoV-2 & MPXV) will be prioritized.
  • Topic MPX6.3: Understanding community groups, structures and needs for development of inclusive, appropriate and tailored interventions
    Please note that a similar topic is open in the SARS-CoV-2 call for proposals (topic SC6.2), and that projects proposing research on both topics (SARS-CoV-2 & MPXV) will be prioritized.
  • Topic MPX6.4: Improved approaches to communicate and engage communities in affected areas (outbreak, epidemic and endemic areas)
  • Topic MPX6.5: Social dimensions of containment and response in evolving current situation.

Apply for MPXV Services

If you don't have an ORCID yet, applying for one takes about one minute and is free. Apply here.
Your organization(Required)
Please briefly describe your research aim as well as the type of capacities that you would need to access.